Receptor for a number of inflammatory CC-chemokines including MIP-1-a, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates. Samson M., Labbe O., Mollereau C. Biochemistry 35:3362-3367(1996) Raport C.J., Gosling J., Schweichart V.L. J. Biol. Chem. 271:17161-17166(1996) Combadiere C., Ahuja S.K., Tiffany H.L., Murphy P.M.J. Leukoc. Biol. 60:147-152(1996)
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