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005235 O-tert-Butyl-dimethylsilyl Curcumin CAS: 911292-36-9

Specifications
References
CAS Number
911292-36-9
Grade
Highly Purified
Molecular Formula
C27H34O6Si
Molecular Weight
482.64
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
RT
(1E,4Z,6E)-ethyl)dimethylsilyl]oxy]-3-methoxyphenyl]-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one

Protected Curcumin. A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.

Form
Brown Gel
Solubility
Chloroform, Dichloromethane, Ethyl Acetate, Methanol
References
Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817
USBio References
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