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006328 4-Chloro Kynurenine-13C2,15N CAS:

Specifications
References
Grade
Highly Purified
Molecular Formula
C813C2H11ClN15NO3
Molecular Weight
245.64
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
α,2-Diamino-4-chloro-γ-oxobenzenebutanoic Acid-13C2,15N; (+/-)-

7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier.  Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application.

Form
Pale Yellow Solid
Melting Point
>205°C (dec.)
Solubility
Aqueous Acid, Aqueous Base
References
Leeson, P., et al.: J. Med. Chem., 37, 4053 (1994), Hilmas, C., et al.: J. Neurosci., 2001, 21, 7463 (2001), Palmer, G., et al.: Curr. Drug Targets, 2, 241 (2001), Wu, H., et al.: Exp. Neurol., 177, 222 (2002),
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