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007102 Crenolanib CAS: 670220-88-9

Specifications
References
CAS Number
670220-88-9
Grade
Highly Purified
Molecular Formula
C26H29N5O2
Molecular Weight
443.54
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
RT
1-[2-[5-[(3-Methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine; ARO 002; CP 868596; [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine;

Crenolanib is a tyrosine kinase inhibitor that acts by specifically inhibiting the receptor tyrosine kinases PDGFRα and PDGFRβ. Crenolanib inhibits the activity of PDGFRα D842V kinase and prevented the phosphorylation of wild type PDGFRα. Crenolanib possesses potential antineoplastic activity. Crenolanib is believed to suppress PDGFR-related signal transduction pathways leading to the inhibition of tumor angiogenesis and tumor cell proliferation.

Form
White to Off-White Solid
Melting Point
217-220°C
Solubility
DMSO, Methanol
References
Michael, M. et al.: Br. J. Cancer, 103, 1554 (2010); Lewis, N.L. et al.: J. Clin. Oncol., 27, 5262 (2009);
USBio References
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