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019101 (S,S)-Palonosetron Hydrochloride CAS: 135729-62-3

Specifications
References
CAS Number
135729-62-3
Grade
Highly Purified
Molecular Formula
C19H25ClN2O
Molecular Weight
332.87
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
(3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride; Aloxi; Onicit; RS-25259-197

Serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic

Melting Point
>280°C (dec)
Specific Rotation
-113° (c = 0.65; water)
Solubility
Methanol, Water
Method for Determining Identity
Proton NMR (CD3OD) spectroscopic analysis and mass spectrometric analysis
TLC Conditions
SiO2; Dichlormethane : Methanol : Ammonium Hydroxide (5: 5 : 1). Visualized with UV and and KMno4 (single spot; Rf= 0.70).
Storage and Stability
Stored at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Source
Synthetic
Purity
~98%
Form
White Solid
References
Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),
USBio References
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