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022718 Valspodar| CAS: 121584-18-7

Specifications
References
CAS Number
121584-18-7
Grade
Highly Purified
Molecular Formula
C₆₃H₁₁₁N₁₁O₁₂
Molecular Weight
1214.62
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic Acid]-7-L-valine-|cyclosporin A; 6-[[R-(E)]-6,7-Didehydro-N,4-dimethyl-3-oxo-L-2-aminooctanoic acid]-7-L-valinecyclosporin A; 6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-|oxo-6-octenoic Acid]ccyclosporin D; Amdray; PSC 833; SDZ-PSC 833; Valpodar;

Antineoplastic adjunct (chemosensitizer).

Melting Point
149-152°C
Solubility
Chloroform (Very Slightly), Methanol (Slightly)
TLC Conditions
Proton NMR (CD3OD) Spectroscopic and Mass Spectrometric Analysis
TLC Conditions
SiO2; Dichloromethane: Methanol; 9:1; Visualized with UV and AMCS; Rf=0.75
Specific Rotation
-274.6ºC (c=0.1, chloroform)
Elemental Analysis
%C:62.30, %H:9.21, %N:12.68
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Boesch, D., et al.: exp. Cell Res., 196, 26 (1991), 2. Lush, R.M., et al.: J. Clin. Pharmacol., 37, 123 (1997). 3. Scott, M.G., et al.: Clin. Chem., 43, 505 (1997). 4. Advani, R., et al.: Blood, 93, 787 (1999).
USBio References
No references available
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