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022874 VX 745 CAS: 209410-46-8

Specifications
References
CAS Number
209410-46-8
Grade
Highly Purified
Molecular Formula
C19H9Cl2F2N3OS
Molecular Weight
436.26
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one;

VX 745 is a potent and selective inhibitor of p38α mitogen-activated protein (MAP) kinase. VX 745 is a potential anti-inflammatory agents. Studies suggest that VX 745 may be useful in the treatment of Werner syndrome.

Form
Pale Yellow Solid
Melting Point
259-262°C (dec.)
Solubility
Chloroform, DMSO, Methanol
References
Haddad, J.J.: Curr. Opin. Invest. Drugs, 2, 1070 (2001); Duffy, J.P. et al.: ACS Med. Chem. Lett., 2, 758 (2011); Bagley, M.C. et al.: Pharmaceuticals, 3, 1842 (2010);
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