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022895 WYE-687 CAS: 1062161-90-3

Specifications
References
CAS Number
1062161-90-3
Grade
Highly Purified
Molecular Formula
C28H32N8O3
Molecular Weight
528.61
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
RT
Methyl 4-(4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d] pyrimidin-6-yl)phenylcarbamate Acid;

WYE-687 is an ATP-competitive and selective inhibitor of mammalian target of rapamycin (mTOR). Studies have shown the combination of Ras-Raf-MEK1/2 inhibitors with WYE-687 may overcome resistance to mTorKIs thus may be an effective additive therapy for treatment of patient with renal cell carcinoma or colorectal cancer.

References
Huang, Shile., et al.: Cell Cycle, 11, 844 (2012); Yu, K., et al.: Cell Rsch., 15, 6232 (2009);
USBio References
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