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162657 Apaziquone CAS: 114560-48-4

Specifications
References
CAS Number
114560-48-4
Grade
Highly Purified
Molecular Formula
C₁₅H₁₆N₂O₄
Molecular Weight
288.3
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
5-(1-Aziridinyl)-3-(hydroxymethyl)-2-[(1E)-3-hydroxy-1-propen-1-yl]-1-methyl-1H-indole-4,7-dione; Apaziquone; EO 9; EO 9 (pharmaceutical); NSC 382456; NSC 382459; (E)-5-(1-Aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-Indole-4,7-dione

Apaziquone is an indolequinone that is a bioreductive prodrug and a chemical analog of Mitomycin C, a chemotherapeutic agent. Apaziquone is a potential therapeutic agent for the treatment of non-muscle invasive bladder cancer.

Synonyms
5-(1-Aziridinyl)-3-(hydroxymethyl)-2-[(1E)-3-hydroxy-1-propen-1-yl]-1-methyl-1H-indole-4,7-dione; Apaziquone; EO 9; EO 9 (pharmaceutical); NSC 382456; NSC 382459; (E)-5-(1-Aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-Indole-4,7-dione
CAS No
114560-48-4
Molecular Formula
C₁₅H₁₆N₂O₄
Molecular Weight
288.3
Purity
≥98%
Appearance
White to off-white powder
Storage and Stability
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Yutkin, V., et al.: Expert. Opin. Investig. Drugs., 21, 251 (2012). 2. Svatek, R.S., et al.: Expert. Rev. Anticancer. Ther., 9, 807 (2009).
USBio References
No references available
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