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207058 Antibiotic PF 1052 CAS: 147317-15-5

Specifications
References
CAS Number
147317-15-5
Grade
Highly Purified
Molecular Formula
C26H39NO4
Molecular Weight
429.6
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
(E)-5-(sec-Butyl)-3-((2-(2,3-dimethyloxiran-2-yl)-6,8-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)(hydroxy)methylene)-1-methylpyrrolidine-2,4-dione

Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma.1,2 It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39ug/ml, respectively), among others.1 It inhibits neutrophil migration in a wound assay using zebrafish larvae expressing GFP-labeled neutrophils, reducing pseudopodia formation and inducing rounding of neutrophils.2 Antibiotic PF 1052 is selective for neutrophil migration over macrophage migration in zebrafish larvae. It also inhibits the migration of murine neutrophils when used at concentrations of 10-20uM. References

Synonyms
(E)-5-(sec-Butyl)-3-((2-(2,3-dimethyloxiran-2-yl)-6,8-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)(hydroxy)methylene)-1-methylpyrrolidine-2,4-dione
CAS Number
147317-15-5
Source
Phoma sp.
Molecular Formula
C26H39NO4
Molecular Weight
429.6
Appearance
Light brown solid
Purity
≥98% (HPLC)
Method for Determining Identity
Proton NMR
Solubility
DMSO, Methanol, Methylene Chloride, Chloroform (all at 10mg/ml)
Storage and Stability
Lyophilized and reconstituted products are are stable for 6 months after receipt. Store at -20°C. Light sensitive
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards:  All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Sasaki, T., Takagi, M., Yaguchi, M., et al. Novel antibiotic PF1052 and its manufacture with Phoma species. Meiji Seika Kaisha, Ltd. JP04316578A (1992). 2. Wang, X., Robertson, A.L., Li, J., et al. Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library. Dis. Model Mech. 7(1), 163-169 (2014). 3. Spylidone, a novel inhibitor of lipid droplet accumulation in mouse macrophages produced by Phoma sp. FKI-1840.: N. Koyama et al.; J. Antibiot. 58: 338 (2005)
USBio References
No references available
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