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217876 Wnt Agonist II, SKL2001 (Wnt Pathway Activator VII, 5-(Furan-2-yl)-N-(3-(1H-imidazol-1-yl)propyl)-1,2-oxazole-3-carboxamide) CAS:

Specifications
Grade
Highly Purified
Molecular Formula
C14H14N4O3
Molecular Weight
286.3
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

A cell-permeable imidazolyl-isoxazolamide that upregulates b-catenin-regulated transcription (CRT; 10-40uM) by disrupting beta-catenin and Axin interaction, thereby preventing b-catenin phosphorylation (Ser33/Ser37/Thr41/Ser45) and proteasomal degradation, without affecting the activities of GSK-3alpha/beta or 18 other kinases (<8.5% inhibition by 10uM SKL2001). Shown to effectively promote osteoblastogenesis in both human and murine mesenchymal cultures (10 to 40uM) as well as suppress MDI- (dexamethasone and insulin) stimulated adipogenesis of murine 3T3-L1 preadipocytes (5 to 30uM).

Formula
C14H14N4O3
Molecular Weight
286.3
Solubility
DMSO (100mg/ml, clear, red solution)
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity
≥95% (HPLC)
Form
Supplied as a pinkish red solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
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