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257180 γ1-MSH CAS: 72629-65-3

Specifications
References
CAS Number
72629-65-3
Grade
Purified
Molecular Formula
Tyr-Val-Met-Gly-His-Phe-Arg-Trp-Asp-Arg-Phe-NH2
Molecular Weight
1512.76
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C
Tyr-Val-Met-Gly-His-Phe-Arg-Trp-Asp-Arg-Phe-NH2; Gamma-1 Melanocyte-stimulating hormone

Endogenous melanocortin MC3 receptor agonist (pKi = 7.46) that displays ~40-fold selectivity over MC4. Increases the release of extracellular dopamine, which induces grooming and vertical activity (rearing) in rats. Exhibits hypertensive, tachycardic and short-term analgesic activity in vivo.

Sequence
Tyr-Val-Met-Gly-His-Phe-Arg-Trp-Asp-Arg-Phe-NH2; Gamma-1 Melanocyte-stimulating hormone
CAS No
72629-65-3
Molecular Weight
1512.76
Appearance
White to off-white solid
Purity
≥97%
Counter Ion
TFA
Solubility
Water, 2mg/ml
Storage
References
Jansone et al (2004) Opposite effects of γ1- and γ2-melanocyte stimulating hormone on regulation of the dopaminergic mesolimbic|system in rats. Neurosci.Lett. 361 68. PMID: 15135895.|Lindblom et al (1998) Autoradiographic discrimination of melanocortin receptors indicates that the MC3 subtype dominates in the|medial rat brain. Brain Res. 810 161. PMID: 9813305.|Versteeg et al (1998) Melanocortins and cardiovascular regulation. Eur.J.Pharmacol. 360 1. PMID: 9845266.
USBio References
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