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274963 Eplerenone CAS: 107724-20-9

Specifications
References
CAS Number
107724-20-9
Grade
Highly Purified
Molecular Formula
C₂₄H₃₀O₆
Molecular Weight
414.49
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
(7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxopregn-4-ene-7,21-dicarboxylic Acid; γ-Lactone 7-Methyl Ester; CGP 30083; Epoxymexrenone; Inspra; SC-66110

Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.

Synonyms
(7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxopregn-4-ene-7,21-dicarboxylic Acid; γ-Lactone 7-Methyl Ester; CGP 30083; Epoxymexrenone; Inspra; SC-66110
CAS
107724-20-9
Molecular Formula
C₂₄H₃₀O₆
Molecular Weight
414.49
Purity (HPLC)
≥98%
Appearance
White to off-white solid
Melting Point
>219°C (dec.)
Solubility
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Storage and Stability
Powder is stable for 6 months after receipt at 4°C.
Important Note
Toxicity and Hazards
 
References
1. de Gasparo, M., et al., J. Pharmacol. Exp. Ther., 240,:650 (1987), 2. Delyani, J.A., et al., Cardiovasc. Drug Rev., 19,:185 (2001), 3. Burgess, E., et al., Expert. Opin. Pharmacother., 5,:2573 (2004), 4. Ravis, W.R., et al., J. Clin. Pharmacol., 45: 810 (2005)
USBio References
No references available
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