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285114 Nelfinavir Mesylate CAS: 159989-65-8

Specifications
References
CAS Number
159989-65-8
Grade
Highly Purified
MDL Number
MFCD00931436
Molecular Formula
C₃₃H₄₉N₃O₇S₂
Molecular Weight
663.89
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
AG-1343, AG1343, Viracept; (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-ph|enylsulfanylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide;methanesulfonic acid

Nelfinavir is a potent competitive inhibitor of the HIV-1 protease. It is reported that it can also inhibit the growth of various cell types and trigger apoptosis. Besides being a protease inhibitor used in the therapeutic agent for acquired immunodeficiency syndrome (AIDS), it is also stimulates autophagy and and exhibits anti-cancer properties. It appears to do by inhibition of the Akt/PKB signaling pathway and activation of endoplasmic reticulum stress with subsequent unfolded protein response (1). Nelfinavir has also been shown to treat SARS-coronavirus (2), and is being tested currently to treat COVID-19.

Synonyms
AG-1343, AG1343, Viracept; (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-ph enylsulfanylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide;methanesulfonic acid
CAS Number
159989-65-8
Molecular Formula
C₃₃H₄₉N₃O₇S₂
Molecular Weight
663.89
Appearance
White solid
Purity
~98%
Melting Point
125-130°C
Purity
~98%
Solubility
DMSO (100mM), Methanol (Slightly)
Storage and Stability
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
Patick, A.K., et al.: Antimicrob. Agents Chemother., 40, 292 (1996), Bardsley-Elliot, G.L., et al.: Drugs, 59, 581 (2000
USBio References
No references available
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