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288929 Ruxolitinib, Free Base CAS: 941678-49-5

Specifications
References
CAS Number
941678-49-5
Grade
Highly Purified
MDL Number
MFCD12031592
Molecular Formula
C17H18N6
Molecular Weight
306.37
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
(b-R)-b-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile; INCB018424, INC18424, NCB018424, NCB18424

Ruxolitinib is a potent and selective Janus kinase (JAK) inhibitor with with IC50's of 2.7 and 4.5nm for JAK1 and JAK2, respectively. Displays clinically significant activity in myelofibrosis. Antineoplastic, anti-inflammatory and immunomodulating agent. Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy.

Synonyms
(b-R)-b-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile; INCB018424, INC18424, NCB018424, NCB18424
CAS No
941678-49-5
Molecular Formula
C17H18N6
Molecular Weight
306.37
Appearance
White to off-white powder
Purity
≥98% (HPLC, TLC)
Solubility
Souble in DMSO at 28mg/ml. Soluble in ethanol at 15mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 25-50uM; buffers, serum or other additives may increase or decrease the aqueous solubility.
Storage and Stability
Powder may be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with DMSO or EtOH. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Light sensitive.
References
1. Shilling, A.D. et al., Drug Metab. Disp., 38, 2023 (2010) 2. Mesa, R.A., IDrugs, 13, 394 (2010) 3. Campas-Moya, C., Drugs Fut., 35, 457 (2010)
USBio References
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