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290169 ∆4-Tibolone CAS: 1162-60-3

Specifications
CAS Number
1162-60-3
Grade
Highly Purified
Molecular Formula
C21H28O2
Molecular Weight
312.45
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
(7α,17α)-17-Hydroxy-7-methyl-19-norpregn-4-en-20-yn-3-one; 17α-Ethynyl-17 -hydroxy-7α-methyl-4-estren-3-one; 7α-Methylnorethindrone; NSC 142228; Org-OM 38

Tibolone is a synthetic steroid with progesterone-like activity. It binds to the progesterone receptor, which is primarily located in the uterus and ovaries. Tibolone has been shown to be an effective treatment for postmenopausal osteoporosis and may also have non-hormonal effects on the central nervous system, such as anti-depressant and anti-anxiety effects. Tibolone binds to the progesterone receptor through a stepwise process, binding more strongly than progesterone due to its substitution of a hydroxyl group at C4 for hydrogen. Tibolone has also been shown to be an effective overtraining prevention agent, by reducing the risk of neural injury during exercise. This drug can also be used as an effective treatment against depression, anxiety and overtraining syndrome.

Synonyms
(7α,17α)-17-Hydroxy-7-methyl-19-norpregn-4-en-20-yn-3-one; 17α-Ethynyl-17 -hydroxy-7α-methyl-4-estren-3-one; 7α-Methylnorethindrone; NSC 142228; Org-OM 38
CAS No
1162-60-3
Molecular Formula
C21H28O2
Molecular Weight
312.45
Appearance
Off-white to pale beige solid
Purity
≥98%
1H NMR (CDCl3), MS
Conforms to reference
TLC Conditions
SiO2; Dichloromethane : Methanol = 7 : 1; Visualized with UV and AMCS; Rf = 0.60.
Elemental Analysis
(Found) %C: 80.43, %H: 8.99; (Calculated) %C: 80.73, %H: 9.03
Specific Rotation
-6.5° (c = 0.1, Chloroform)
Solubility
Chloroform (Slightly), Methanol (Slightly)
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
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