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291899 Vandetanib CAS: 443913-73-3

Specifications
References
CAS Number
443913-73-3
Grade
Highly Purified
Molecular Formula
C22H24BrFN4O2
Molecular Weight
475.35
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine; 4-(4-Bromo-2-fluoroanilino)-6-methoxy-|7-[(1-methylpiperidin-4-yl)methoxy]quinazoline; ZD 6474; Zactima

Vandetanib is a once-daily oral inhibitor of vascular endothelial growth factor receptor-2 and epidermal growth factor receptor kinase activity. The activity of Vandetanib plus Docetaxel was assessed in patients with previously treated non-small-cell lung cancer (NSCLC).

Alternate Name
N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine; 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline; ZD 6474
CAS Number
443913-73-3
Molecular Formula
C22H24BrFN4O2
Molecular Weight
475.35
Appearance
White to pale yellow powder
Purity
≥98.5%
Loss on Drying
≤0.5%
Identity (1H NMR)
Conforms to structure
Storage
4°C
References
1. Bruns, C., et al., Clin. Cancer Res., 6, 1936 (2000)|2. Hennequin, L., et al., J. Med. Chem., 45, 1300 (2002)|3. Park, M., et al., J. Biol. Chem., 278, 50624 (2003)|4. Arao, T., et al., Cancer Res., 64, 9101 (2004
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