USBio Logo

A2296-90 Anisomycin (Flagecidin, Antibiotic SA 3097C1, Antibiotic PA 106, Anhydroscopin A, NSC) CAS: 22862-76-6

Specifications
References
CAS Number
22862-76-6
Grade
Highly Purified
Molecular Formula
C14H19NO4
Molecular Weight
265.3
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
((2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate, 2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate

Anisomycin is a phenylmethylenepyrrolidine first isolated from Streptomyces griseolus in 1954 as an antiprotozoan with antifungal activity. Anisomycin acts as an inhibitor of protein synthesis by binding to the 60S ribosomal subunit. Interestingly, anisomycin has found use for the induction of amnesia in animal models. More recently, anisomycin has been demonstrated to induce apoptosis, to be a selective signalling agonist, to activate mitogen-activated protein (MAP) kinases and to be immunomodulatory via its action on T cells.

Soubility (10mg/ml EtOAc)
Colorless, clear, complete
Assay (HPLC): ≥98%
Melting Point: 139-145ºC
Water (KF): ≤1%
Ethyl Acetate (GC-MS): ≤0.72%
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with ethyl acetate. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Protect from light and moisture.
Source
Streptomyces griseolus
Form
Supplied as a white crystalline powder
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Anisomycin, a new antiprotozoa antibiotic. Sobin B.A. & Tanner F.W. Jr., J. Am. Chem. Soc. 1954, 76, 4053 2. Selective inhibition of caspases during apoptotic induction in HL-60 cells. Effects of a tetrapeptide inhibitor. Polverino A.J. & Patterson S.D., J. Biol. Chem. 1997, 272, 7013. 3. Evidence of two mechanisms for the activation of the glucose transporter GLUT1 by anisomycin: p38 (MAP kinase) activation and protein synthesis inhibition in mammalian cells. Barros L.F. et al., J. Physiol. 1997, 504, 517. 4. Anisomycin inhibits the behaviors of T cells and the allogeneic skin transplantation in mice. Xing F. et al., J. Immunother. 2008, 31, 858.
USBio References
No references available
Pricing
Order
Proceed to Checkout
Cart Summary
ProductSizeListYour PriceQtyExt Price
Subtotal:Subtotal:
Subtotal:Subtotal:
Total Coupon Savings:Total Coupon Savings:()
Your cart is currently empty.
- Coupon Code
Recently Viewed
  • Contact Us

    Visit our technical library or contact our support staff to answer your questions.

    Telephone:
    1-800-520-3011

    Library | Contact

    Distributors

    For customers outside of the United States, please use one of our many distributors.

    View Distributors

    Payment Methods

    We accept the following payment methods as well as pay-by-invoice.

    MasterCard Visa PayPal
    © 2023-2024 United States Biological - All Rights Reserved