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H9117-93D (Z)-4-Hydroxytamoxifen CAS: 68047-06-3

Specifications
References
CAS Number
68047-06-3
Grade
Highly Purified
MDL Number
MFCD00278780
Molecular Formula
C26H29NO2
Molecular Weight
387.51
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen; 4-Hydroxy-(Z)-tamoxifen; 4-Hydroxytamoxifen; Hydroxytamoxifen; ICI 79280

(Z)-4-Hydroxy Tamoxifen is a metabolite of Tamoxifen. (Z)-4-Hydroxy Tamoxifen is a hydroxylated analogue of Tamoxifen. (Z)-4-Hydroxy Tamoxifen is a metabolite of Tamoxifen with anti-estrogenic properties. Estrogen receptor modulator. Activates intein-linked inactive Cas9 to reduce off target effects of CRISPR-mediated gene editing.

CAS No
68047-06-3
Synonyms
4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen; 4-Hydroxy-(Z)-tamoxifen; 4-Hydroxytamoxifen; Hydroxytamoxifen; ICI 79280
Molecular Formula
C26H29NO2
Molecular Weight
387.51
Purity
≥99%
Appearance
White to off-white solid
Method for Determining Identity
1H NMR Spectrum and Liquid Chromatograpty Mass Spectrometry Analysis
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C for 6 months after receipt.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Ruenitz, P.C. et al.: J. Med. Chem., 25, 1056 (1982). 2. Ogura, K., et al.: Biochem. Pharmacol., 71, 1358 (2006). 3. Oleson, L., et al.: J. Pharm. Pharmacol., 60, 1175 (2008)
USBio References
No references available
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