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R1988 Reveromycin A CAS: 134615-37-5

Specifications
References
CAS Number
134615-37-5
Grade
Highly Purified
Molecular Formula
C36H52O11
Molecular Weight
660.8
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Reveromycin A, the dominant analogue of a complex of spiroketals isolated from a Streptomyces sp., is an inhibitor of the mitogenic activity of epidermal growth factor (EGF). It is a G1 phase cell cycle inhibitor, selectively inhibiting isoleucyl-tRNA synthetase. Reveromycin A displays antiproliferative behavior against human cell lines KB and K562 as well as potent antifungal activity. More recently it has been shown to inducing apoptosis in osteoclasts thus inhibiting bone resorption.

Purity: >99% by HPLC
Solubility: Soluble in ethyl acetate, ethanol, methanol, DMF or DMSO. Avoid acidic conditions.
Related to: Reveromycin B, Reveromycin C, Reveromycin D
Source
Streptomyces sp.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in |osteoclasts. Woo J.T. et al. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 4729. |2. Reveromycin A inhibits osteolytic bone metastasis of small-cell lung cancer cells, SBC-5, through an |antiosteoclastic activity. Muguruma H. et al. Clin. Cancer Res. 2005, 11, 8822. |3. Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific |inhibitor Reveromycin A. Miyamoto Y. et al. J. Biol. Chem. 2002, 277, 28810. |4. Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities. Takahashi H. et al. J. |Antibiot. 1992, 45, 1414.
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