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V2121-47D Venturicidin B (Aabomycin A2) CAS: 33538-72-6

Specifications
References
CAS Number
33538-72-6
Grade
Highly Purified
Molecular Formula
C40H66O10
Molecular Weight
706.95
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
+4°C
Aabomycin A2

The macrolide antibiotic Venturicidin B, isolated from a Streptomyces sp., is a potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector. Originally isolated as an antifungal agent.

Purity: >95% by HPLC
Solubility: Soluble in ethanol, methanol, DMF or DMSO.
Related to: Venturicidin A
Source
Streptomyces sp.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Potassium selective and venturicidin sensitive conductances of Fo purified from bovine heart |mitochondria, reconstituted in planar lipid bilayers. Miedema H. et al. Biochem. Biophys. Res. Commun. |1994, 203, 1005. |2. Studies on the mechanism of oxidative phosphorylation. ATP synthesis by submitochondrial particles |inhibited at F0 by venturicidin and organotin compounds. Matsuno-Yagi A. & Hatefi Y. J. Biol. Chem. |1993, 268, 6168. |3. Amino acid substitutions in mitochondrial ATP synthase subunit 9 of Saccharomyces cerevisiae leading |to venturicidin or ossamycin resistance. Galanis M. et al. FEBS Lett. 1989, 249, 333.
USBio References
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