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001269 2-Acetyl-6-(dimethylamino)naphthalene (2-ADN) CAS: 68520-00-3

Specifications
CAS Number
68520-00-3
Grade
Highly Purified
MDL Number
MFCD12024642
Molecular Formula
C₁₄H₁₅NO
Molecular Weight
213.28
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
1-[6-(Dimethylamino)-2-naphthalenyl]-ethanone; 1-(6-Dimethylaminonaphthalen-2-yl)ethanone; Acdan; Acedan; 2-ADN|

2-Acetyl-6-(dimethylamino)naphthalene (2-ADN) is a fluorescent probe that has been shown to react with nucleic acids. 2-ADN is an acyl chain analog of the natural substrate, naphthoquinone. 2-ADN reacts with dsDNA and RNA by intercalating between the bases in the DNA duplex or RNA strand and then reacting with the nucleobases at the ends of each strand to form a covalent bond. The reaction rate can be increased by increasing the length of the acyl chain. In vitro studies have shown that 2-ADN binds preferentially to euchromatin regions of chromosomes, which are regions rich in gene activity. Fluorescence assays have also shown that 2-ADN binds to wild type strains more efficiently than mutant strains.

Synonyms
1-[6-(Dimethylamino)-2-naphthalenyl]-ethanone; 1-(6-Dimethylaminonaphthalen-2-yl)ethanone; Acdan; Acedan; 2-ADN
CAS No
68520-00-3
Molecular Formula
C₁₄H₁₅NO
Molecular Weight
213.28
Appearance
Light yellow to yellow solid
Purity
≥98%
Melting Point
149-153°C
Solubility
Chloroform (Slightly), Ethyl Acetate (Slightly, Sonicated)
Storage and Stability
Store at 4°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
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