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005436 (R)-tert-Butylsulfinamide CAS: 196929-78-9

Specifications
References
CAS Number
196929-78-9
Grade
Highly Purified
MDL Number
MFCD05861479
Molecular Formula
C4H11NOS
Molecular Weight
121.2
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
(R)-(+)-2-Methyl-2-propanesulfinamide; (R)-N-tert-Butanesulfinamide;|(R)-tert-Butanesulfinamide; (R)-(+)-t-Butyl sulfinamide

(R)-tert-Butylsulfinamide is a chiral ligand used in pharmaceutical compositions. (R)-tert-Butylsulfinamide can be readily transformed into P,N-sulfinyl imine ligands through condensation with aldehydes and ketones, which can undergo iridium-catalyzed asymmetric hydrogenation of olefins.

(R)-(+)-2-Methyl-2-propanesulfinamide may be used to prepare N-(1-cyclohexylmethylidene)-2-methylpropane-2-sulfinamide via copper mediated condensation with cyclohexane carboxaldehyde. It may also be used to prepare (20E)-N-[t-butyl-(R)-sulfinyl]-3β-(t-butyldimethylsilyloxy)-pregn-5-en-20-imine, an intermediate for the development of androgen receptor antagonists.
Synonyms
(R)-(+)-2-Methyl-2-propanesulfinamide; (R)-N-tert-Butanesulfinamide; (R)-tert-Butanesulfinamide; (R)-(+)-t-Butyl sulfinamide
CAS No
196929-78-9
Molecular Formula
C4H11NOS
Molecular Weight
121.2
Appearance
Off-white to yellow solid
Purity
≥97%
Melting Point
103-107°C (lit.)
Solubility
Chloroform
Storage
4°C
References
Szallasi, A., et al.: Pharmacol. Rev., 51, 159 (1999),
USBio References
No references available
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