Carboxyphosphamide CAS 22788-18-7

CAS Number

22788-18-7

Grade

Highly Purified

MDL Number

MFCD01722742

Molecular Formula

C₇H₁₅Cl₂N₂O₄P

Molecular Weight

293.08

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

3-[[Amino[bis(2-chloroethyl)amino]phosphinyl]oxy]propanoic Acid; N,N-Bis(2-chloroethyl)phosphorodiamidate Hydracrylic Acid; Asta 5754; Carboxycyclophosphamide; NSC 145124

A metabolite of Cyclophosphamide (CPA). It is formed from cyclophosphamide via oxidation of the intermediate metabolite aldophosphamide by aldehyde dehydrogenase.

Synonyms

3-[[Amino[bis(2-chloroethyl)amino]phosphinyl]oxy]propanoic Acid; N,N-Bis(2-chloroethyl)phosphorodiamidate Hydracrylic Acid; Asta 5754; Carboxycyclophosphamide; NSC 145124

CAS No

22788-18-7

Molecular Formula

C₇H₁₅Cl₂N₂O₄P

Molecular Weight

293.08

Appearance

White to off-white solid

Purity

≥98%

Melting Point

105-108°C

Solubility

Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly)

Storage and Stability

May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

References

1. Takamizawa, A., et al.: J. Med. Chem., 18, 376 (1975)|2. Jones, R.J., et al.: J. Hematother., 1, 343 (1992)|3. Biggs, D., et al.: Prog. Clin. Biol. Res., 389, 9 (1994)|4. Manthey, C.L., and Sladek, N.E. Kinetic characterization of the catalysis of "activated" cyclophosphamide (4-hydroxycyclophosphamide/aldophosphamide) oxidation to carboxyphosphamide by mouse hepatic aldehyde dehydrogenases. Biochem. Pharmacol. 37(14), 2781-2790 (1988).

USBio References

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005752 Carboxyphosphamide CAS: 22788-18-7

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MDL Number

Molecular Formula

Molecular Weight

EU Commodity Code

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3-[[Amino[bis(2-chloroethyl)amino]phosphinyl]oxy]propanoic Acid; N,N-Bis(2-chloroethyl)phosphorodiamidate Hydracrylic Acid; Asta 5754; Carboxycyclophosphamide; NSC 145124

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