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007125 Curcumin-d6 CAS: 1246833-26-0

Specifications
References
CAS Number
1246833-26-0
Grade
Highly Purified
Molecular Formula
C21H14D6O6
Molecular Weight
374.42
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione-d6; (E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione-d6; C Yellow 15-d6; C.I. 75300-d6; Curcuma-d6; Curcumine-d6; Diferuloylmethane-d6; Haidr-d6; Halad-d6; Haldar-d6; Ukon-d6

Labeled Curcumin. A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.

Synonyms
(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione-d6; (E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione-d6; C Yellow 15-d6; C.I. 75300-d6; Curcuma-d6; Curcumine-d6; Diferuloylmethane-d6; Haidr-d6; Halad-d6; Haldar-d6; Ukon-d6
CAS Number
1246833-26-0
Molecular Formula
C21H14D6O6
Molecular Weight
374.42
Purity
Chemical Purity: ~98%; Isotopic Purity: ~99%
Form
Orange to dark orange solid
Melting Point
184-186°C (lit)
Solubility
Chloroform (Slightly Sonicated), DMSO (Slightly)
Method for Determining Identity
Proton NMR Spectroscopic and Mass Spectrometric Analysis
Normalized Intensity
d0=0.03%, d1=0.10%, d2=0.00%, d3=0.12%, d4=0.06%, d5=0.00%, d6=99.69%
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at 4ºC for 6 months after time of receipt.
References
1. Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), 2. Tu, B., et al.: J .Cell Biol., 164, 341 (2004), 3. Xu, G., et al.: Biochemistry, 44, 9817
USBio References
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