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007917 Delanzomib CAS: 847499-27-8

Specifications
References
CAS Number
847499-27-8
Grade
Highly Purified
Molecular Formula
C21H28BN3O5
Molecular Weight
413.28
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
RT
[(1R)-1-[[(2S,3R)-3-Hydroxy-1-oxo-2-[[(6-phenyl-2-pyridinyl)carbonyl]amino]butyl]amino]-3-methylbutyl]boronic Acid; CEP 18770; CIP 18770; CT 47098; NPH 007098; [(1R)-1-[[(2S,3R)-3-Hydroxy-2-[[(6-phenylpyridin-2-yl)carbonyl]amino]-1-oxobutyl]amino]-3-methylbutyl]boronic Acid;

Delanzomib is an orally active proteasome inhibitor. Delanzomib has been shown to down-modulate NF-κB, induce apoptosis, inhibit angiogenesis and M-CSF-RANKL-induced osteoclastogenesis.

References
Piva, R. et al.: Blood, 111, 2765 (2008); Sanchez, E. et al.: Br. J. Haematol., 148, 569 (2010);
USBio References
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