Desoxymetasone CAS 382-67-2

CAS Number

382-67-2

Grade

Purified

Molecular Formula

C₂₂H₂₉FO₄

Molecular Weight

376.46

EU Commodity Code

38220090

Shipping Temp

Storage Temp

4°C

(11β,16α)-9-Fluoro-11,21-dihydroxy-16-methyl-pregna-1,4-diene-3,20-dione; 17-Deoxydexamethasone; 9-Fluoro-16α-methyl-1-corticosterone; Desoximetasone; Stidex; Topicort; Topicorte; Topisolon

Glucocorticoid anti-inflammatory. It is also found as an impurity in Dexamethasone.

Synonyms

(11β,16α)-9-Fluoro-11,21-dihydroxy-16-methyl-pregna-1,4-diene-3,20-dione; 17-Deoxydexamethasone; 9-Fluoro-16α-methyl-1-corticosterone; Desoximetasone; Stidex; Topicort; Topicorte; Topisolon

CAS Number

382-67-2

Molecular Formula

C₂₂H₂₉FO₄

Molecular Weight

376.46

Appearance

White to off-white crystalline powder

Purity

97-103%

Identification A, B

Conforms

Residue on Ignition

≤0.2%

Melting Point

206-218ºC

Heavy Metals

≤0.002%

Residual Solvent

Methanol: ≤3000ppm Dichloromethane: ≤600ppm Ethyl Acetate: ≤5000ppm

Specific Optical Rotation

+107 to +112°

Solubility

Chloroform (Slightly), Methanol (Slightly)

Loss on Drying

≤1%

Particle Size

99% (<30 micron)

Storage

4°C

Meets or exceeds USP39

References

Schriks, M., et al.: Environ. Sci. Technol., 44, 4766 (2010), Baeck, M., et al.: Eur. J. Dermatol., 20, 102 (2010), Lee, P., et al.: Bioorg. Med. Chem. Lett., 20, 69 (2010)