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009121 L-Dicentrine CAS: 28832-07-7

Specifications
References
CAS Number
28832-07-7
Grade
Highly Purified
Molecular Formula
C20H21NO4
Molecular Weight
339.39
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
RT
(7aR)-6,7,7a,8-Tetrahydro-10,11-dimethoxy-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline; 9,10-Dimethoxy-1,2-(methylenedioxy)-6aβ-aporphine; (R)-6,7,7a,8-Tetrahydro-10,11-dimethoxy-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline; (-)-Dicentrine; (R)-(-)-Dicentrine; NSC 251699; ||

A natural vascular alpha 1-adrenoceptor antagonist but less prevalent than the D-isomer. It markedly inhibits the contraction of rat stomach muscle strips induced by 5-HT, histamine, K+ and Ca2+ after high K+ depolarization, showing a non-competitive antagonism and could be a potential muscle relaxant. Studies suggest that it has protective effect of on acute myocardial Iichemia and anoxia lesion.

References
Li, H. et al.: Zhong. Zhon. Zaz., 25, 426 (2000); Li, M. et al.: Acad. J. Kun. Med. Coll., 1003 (1997); Teng, C.M. et al.: Brit, J. Pharmacol., 104, 651 (1991);
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