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012765 Gentamicin C1a Pentaacetate Salt CAS: 26098-04-4

Specifications
References
CAS Number
26098-04-4
Grade
Highly Purified
Molecular Formula
C29H59N5O17
Molecular Weight
749.8
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1-4)]-2-deoxy-D-streptamine Pentaacetate Salt; Gentamicin D Acetate; Gentamycin C1a Acetate; Gentamicin C3 Acetate

Gentamicin C1a pentaacetate is a prodrug that is converted to gentamicin, its active form, by the enzyme diacetyl reductase. Gentamicin C1a pentaacetate has minimal toxicity and can be used for the treatment of infections caused by gram-positive species. This drug has been shown to be effective against bowel disease and infectious diseases. Gentamicin C1a pentaacetate is enzymatically inactivated by the wild-type strain of Escherichia coli and other gram-negative bacteria. The matrix effect may affect the pharmacokinetics of this drug, which can be studied using an analytical method.

Synonyms
O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1-4)]-2-deoxy-D-streptamine Pentaacetate Salt; Gentamicin D Acetate; Gentamycin C1a Acetate; Gentamicin C3 Acetate
CAS No
26098-04-4
Molecular Formula
C29H59N5O17
Molecular Weight
749.80 (449.55 + 5(60.05))
Appearance
White to beige solid
Purity
≥95%
Method for Determining Identity
Proton NMR (D2O) Spectroscopic and Mass Spectrometric. Conforms to reference
Melting Point
112-115°C
Specific Rotation
+97.1° (c = 0.2, Water)
Water
~3.7% based on Elemental Analysis
Solubility
Methanol (Slightly), Water (Slightly)
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Hygroscopic, Under Inert Atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
Holt, H.A., et al.: J. Antimicrob. Chemother., 34, 747 (1994), Wilschanski, M., et al.: Am. J. Respir. Crit. Care Med., 161, 860 (2000),
USBio References
No references available
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