Hydroxy Fasudil Hydrochloride CAS 155558-32-0

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013806 Hydroxy Fasudil Hydrochloride CAS: 155558-32-0

Specifications

References

CAS Number

155558-32-0

Grade

Highly Purified

Molecular Formula

C14H18ClN3O3S

Molecular Weight

343.83

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine Hydrochloride; |5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-1(2H)-isoquinolinone; HA1100 Hydrochloride;

A metabolite of Fasudil. A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties. Reported to inhibit the Rho kinase-mediated (ROCK) contraction both in vitro and in vivo.

Form

Off-White Solid

Melting Point

>250 (dec.)

Solubility

Aqueous Acid, Methanol (Sparingly)

References

Shimokawa, H., et al.: Cardiovasc. Res., 43, 1029 (1999), Takemoto, M., et al.: Circulation, 106, 57 (2002), Ito, K., et al.: J. Physiol., 546, 823 (2003),