5-Iodouracil CAS 696-07-1

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014915 5-Iodouracil CAS: 696-07-1

Specifications

References

CAS Number

696-07-1

Grade

Highly Purified

Molecular Formula

C4H3IN2O2

Molecular Weight

237.98

EU Commodity Code

38220090

Shipping Temp

Storage Temp

4°C

5-Iodo-2,4(1H,3H)-pyrimidinedione; 5-Iodo-2,4-dihydroxypyrimidine; 5-Iodo-2,4-pyrimidinedione; 5-Iodopyrimidine-2,4-diol; 5-Iodouracil; NSC 57848;

5-Iodouracil is a halogenated pyrimidine that can be used in nucleoprotein photo-crosslinking via RNA substitution. 5-Iodouracil is used in thymidine phosphorylase targeted imaging and therapy. Studies show that DNA N-glycosylase MED1 exhibited higher preference for 5-Iodouracil and halogenated bases over non-halogenated ones.

Form

Off-White Solid

Melting Point

266-270°C

Solubility

DMSO, Methanol

References

Meisenheimer, K. et al.: Meth. Enzymol., 318, 88 (2000); Klecker, R.W. Jr. et al.: Cancer Chemother. Pharmacol., 48, 407 (2001); Turner, D.P. et al.: Cancer Res., 66, 7686 (2006);