Losartan Carboxaldehyde CAS 114798-36-6

CAS Number

114798-36-6

Grade

Highly Purified

Molecular Formula

C22H21ClN6O

Molecular Weight

420.89

EU Commodity Code

38220090

Shipping Temp

Storage Temp

4°C

2-Butyl-4-chloro-1-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde; EXP 3179; DUP 167; Losartan EP Impurity K; Losartan USP Related Compound C

A metabolite of Losartan. An intermediate in the synthesis of the EXP 3174.

Synonyms

2-Butyl-4-chloro-1-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde; EXP 3179; DUP 167; Losartan EP Impurity K; Losartan USP Related Compound C

CAS No

114798-36-6

Molecular Formula

C22H21ClN6O

Molecular Weight

420.89

Appearance

Off-white to light yellow solid

Purity

≥95%

Melting Point

>71°C (dec.)

Solubility

Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)

Storage and Stability

May be stored at RT for short-term only. Long-term storage is recommended at 4°C. Hygroscopic. Under Inert Atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards

All products should be handled by qualified personnel only, trained in laboratory procedures.

References

1. Krämer, C., Sunkomat, J., Witte, J., et al. Angiotensin II receptor-independent antiinflammatory and antiaggregatory properties of losartan: Role of the active metabolite EXP3179. Circ. Res. 90(7):770-776 (2002), 2. Schupp, M., Lee, L.D., Frost, N., et al. Regulation of peroxisome proliferator-activated receptor γ activity by losartan metabolites. Hypertension 47(3):586-589 (2006), 3. Kappert, K., Tsuprykov, O., Kauffman, J., et al. Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARγ activation. Hypertension 54(4):738-743 (2009), 4. Pieter, B.M.W.M., et al.: Hypertension, Supp. III, 18:5, (1991), 5. Chang, L.L., et al.: J. Med. Chem., 36:2558 (1993)

USBio References

No references available

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015678 Losartan Carboxaldehyde CAS: 114798-36-6

CAS Number

Grade

Molecular Formula

Molecular Weight

EU Commodity Code

Shipping Temp

Storage Temp

2-Butyl-4-chloro-1-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde; EXP 3179; DUP 167; Losartan EP Impurity K; Losartan USP Related Compound C

References

USBio References

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