Lumiflavin CAS 1088-56-8

CAS Number

1088-56-8

Grade

Highly Purified

Molecular Formula

C13H12N4O2

Molecular Weight

256.26

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

7,8,10-Trimethylbenzo[g]pteridine-2,4(3H,10H)-dione; 4-hydroxy-7,8,10-trimethylbenzo[g]pteridin-2(10H)-one; Lumiflavine; 7,8,10-Trimethylisoalloxazine

Lumiflavine is a structural analog of the water-soluble vitamin riboflavin that has been used to study the mechanism of uptake of riboflavin into intestinal epithelial (Caco-2) and human retinal pigment epithelial (hRPE) cells.1,2 It inhibits the uptake of radiolabeled riboflavin approximately 3-fold (at 25uM) and 30-fold (at 10uM) in Caco-2 cells and hRPE cells, respectively.1,2

Synonyms

7,8,10-Trimethylbenzo[g]pteridine-2,4(3H,10H)-dione; 4-hydroxy-7,8,10-trimethylbenzo[g]pteridin-2(10H)-one; Lumiflavine; 7,8,10-Trimethylisoalloxazine

CAS Number

1088-56-8

Molecular Formula

C13H12N4O2

Molecular Weight

256.26

Purity

≥95%

Form

Supplied as a yellow to green crystalline solid

Melting Point

320-330°C (lit)

Storage and Stability

Store at -20°C long-term. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.

Source

Synthetic

Purity

≥95%

Form

Supplied as a yellow to green crystalline solid

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Said, H.M., and Ma, T.Y. Mechanism of riboflavine uptake by Caco-2 human intestinal epithelial cells Am. J. Physiol. 266( 1 pt 1), G15-G21 (1994). 2. Said, H.M., Wang, S., and Ma, T.Y. Mechanism of riboflavin uptake by cultured human retinal pigment epithelial ARPE-19 cells: Possible regulation by an intracellular Ca2+-calmodulin-mediated pathway J. Physiol. 556 (Pt 2), 369-377 (2005). 3. Zhao, X. et al.: Chemosphere, 63:1116 (2006) 4. Litke, S.V. et al.: Khim. Fiz., 10:48 (1991) 5. Ye, W. et al.: Guang. Yaox. Xueb., 12:175 (1996)

USBio References

No references available

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015703 Lumiflavin CAS: 1088-56-8

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Grade

Molecular Formula

Molecular Weight

EU Commodity Code

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7,8,10-Trimethylbenzo[g]pteridine-2,4(3H,10H)-dione; 4-hydroxy-7,8,10-trimethylbenzo[g]pteridin-2(10H)-one; Lumiflavine; 7,8,10-Trimethylisoalloxazine

References

USBio References

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