6-Methylthioguanine CAS 1198-47-6

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017448 6-Methylthioguanine CAS: 1198-47-6

Specifications

References

CAS Number

1198-47-6

Grade

Highly Purified

Molecular Formula

C6H7N5S

Molecular Weight

181.22

EU Commodity Code

38220090

Shipping Temp

Storage Temp

6-(Methylthio)-1H-purin-2-amine; 2-Amino-6-methylmercaptopurine; NSC 29420; 2-Amino-6-methylthiopurine; S-Methyl-6-thioguanine; S6-Methyl-6-thioguanine;

A metabolite of 2’-Deoxy-6-thio Guanosine and 6-Thioguanine. An effective immunosuppressant and anticancer agent, however chronic exposure can be mutagenic in human cells as long-term use of thiopurines was found to be associated with a significantly increased risk of various types of cancer.

References

Loo, T.L. et al.: Cancer Chemother. Pharmacol., 6, 131 (1981); Yuan, B. et al.: ACS Chem. Biol., 5, 1021 (2010); Kroplin, T. et al.: Adv. Exp. Med. Biol., 431, 741 (1998);