8-Nitroguanosine CAS 337536-53-5

CAS Number

337536-53-5

Grade

Purified

Molecular Formula

C₁₀H₁₂N₆O₇

Molecular Weight

328.24

EU Commodity Code

38220090

Shipping Temp

Storage Temp

-20°C

A highly reactive redox-active nucleic acid derivative that is is formed in cellular RNA as biomarker of exposure to reactive nitrogen species. Recent studies suggest that it might contribute to the pathogenesis of inflammation-associated carcinogenesis.

Melting Point

As Reported

Solubility

As Reported

Method for Determining Identity

Proton NMR (D2O, DMSO-d6) Spectroscopic and Mass Spectrometric Analysis

TLC Conditions

As Reported

Elemental Analysis

As Reported

Methanol Content

As Reported

Storage and Stability

May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards

All products should be handled by qualified personnel only, trained in laboratory procedures

References

1. Sawa, T. et al.: Biochem. Biophys. Res. Comm., 311, 300 (2003). 2. Masuda, M. et al.: Chem.-Biol. Inter., 139, 187 (2002). 3. Kaneko, K. et al.: Cancer Lett., 262, 239 (2008);