PD-123319 Bis CAS

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019154 PD-123319 Bis(trifluoroacetate) Salt Hydrate CAS:

Specifications

References

Grade

Highly Purified

Molecular Formula

C31H32N4O3•2C2HF3O2•xH2O

Molecular Weight

736.66

EU Commodity Code

38220090

Shipping Temp

Storage Temp

4°C

(6S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic Acid Bis(trifluoroacetate) Salt Hydrate; (S)-(+)-PD 123319 Bis(trifluoroacetate) Salt Hydrate;

A selective and potent non-peptide angiotensin II type 2 (AT2) receptor antagonist. Potential treatment of cardiac hypertrophy as blockage of AT2 receptor prevents thyroxine-mediated cardiac hypertrophy by blocking Akt activation. Studies show that it has protective effect against tumor necrosis factor-α-induced damage to human renal proximal tubular epithelial cells

Form

Pale Beige Solid

Melting Point

111-114°C

Solubility

Chloroform, Methanol

Pfizer Compound

References

Carmeiros-Ramos, M.S. et al.: Bas. Res, Cardiol., 105, 325 (2010); Kagawa, T. et al.: Nephrol., 13, 309 (2008); Cohen, E.P. et al.: Transl. Res., 150, 106 (2007);