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019326 PF-4800567 Hydrochloride CAS:

Specifications
References
Grade
Highly Purified
Molecular Formula
C17H19Cl2N5O2
Molecular Weight
396.27
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
RT
3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Hydrochloride; PF 4800567 Hydrochloride;

PF 4800567 is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock.

Pfizer Compound
References
Behrend, L., et al.: Oncogene, 19, 5303 (2000), Badura, L., et al.: J. Pharmacol. Exp. Ther., 322, 730 (2007), Arora, S., et al.: Cancer Res., 69, 1910 (2009), Walton, et al.: J. Pharmacol. Exp. Ther., 330, 430 (2009),
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