Pitavastatin-d5 Lactone CAS

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019819 Pitavastatin-d5 Lactone CAS:

Specifications

References

Grade

Highly Purified

Molecular Formula

C25H17D5FNO3

Molecular Weight

408.48

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

(4R,6S)-6-[(1E)-2-[2-(Cyclopropyl-d5)-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-one; [4R-[4α,6β(E)]]-6-[2-[2-(Cyclopropyl-d5)-4-|(4-fluorophenyl)-3-quinolinyl]ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-one; NK 104-d5; NK 104-d5 (lactone); Nisvastatin-d5; P 872441-d5; |

A labeled metabolite of Pitavastatin. Recent studies have shown that conversion between acid and lactone forms occurs in the body, drug-drug interaction should be considered on both acid and lactone forms. The inhibitory effects of statins on CYP metabolic activities and MDR1 transporting activity were investigated using human liver microsomes and MDR1-overexpressing LLC-GA5-COL150 cells

Form

Off-White to Pale Yellow Solid

Melting Point

72-75°C

Solubility

Chloroform, Ethyl Acetate

References

Wang, J., et al.: Drug Metab. Dispos., 30, 1352 (2002), Yamada, I., et al.: Xenobiotica, 33, 789 (2003), Fujino, H., et al.: Xenobiotica, 34, 961 (2004),