RTI-113 CAS 141807-57-0

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020771 RTI-113 CAS: 141807-57-0

Specifications

References

CAS Number

141807-57-0

Grade

Highly Purified

Molecular Formula

C21H23Cl2NO2

Molecular Weight

392.32

EU Commodity Code

38220090

Shipping Temp

Storage Temp

(1R,2S,3S,5S)-3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic Acid Phenyl Ester Hydrochloride; [1R-(exo,exo)]-3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic Acid Phenyl Ester Hydrochloride; RTI 113; RTI 4229-113;

RTI-113 is a 3-phenyltropane analogue that acts as a potent and selective dopamine uptake inhibitor. RTI-113 has been shown to reduce cocaine self-administration at high occupancy of dopamine transporter. Studies suggest that RTI-113 and its analogs may be useful tools for developing potential agonist therapies for cocaine dependence.

References

Dworkin, S. et al.: Synapse, 30, 49 (1998); Negus, S.S. et al.: Pharmacol. Biochem. Behav., 91, 333 (2009); Cook, C. et al.: Eur. J. Pharmacol., 442, 93 (2002);