SAG CAS 912545-86-9

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020808 SAG CAS: 912545-86-9

Specifications

References

CAS Number

912545-86-9

Grade

Highly Purified

MDL Number

MFCD22581513

Molecular Formula

C28H28ClN3OS

Molecular Weight

490.06

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

A potent agonist of Hedgehog (Hh) signalling by activating the Smoothened (Smo) protein function. Studies identify novel properties of molecules displaying potential interest in the treatment of various cancers and brain diseases, and demonstrate that Smo is capable of signaling through G15.

Synonyms

3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]- benzo[b]thiophene-2-carboxamide

CAS Number

912545-86-9

Molecular Weight

490.06

Molecular Formula

C₂₈H₂₈ClN₃OS

Solubility

Water

Appearance

Supplied as an orange to red oil.

Storage and Stability

Store at -20°C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

References

1. DeCamp, D., et al.: J. Biol. Chem., 275, 26322 (2000)|2. Ahn, S., et al.: Nature, 437, 894 (2005)|3. Huangfu, D., et al.: Development, 133, 3 (2006)|4.Loulier, K., et al.: J. Neurochem., 98, 530 (2006)