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020857 SC-58236 CAS: 170569-86-5

Specifications
References
CAS Number
170569-86-5
Grade
Highly Purified
Molecular Formula
C16H11ClF3N3O2S
Molecular Weight
401.79
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
4-[5-(4-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide; SC-58236; SC-236;

A highly selective and potent cyclooxygenase-2 inhibitor which has been shown to induce apoptosis in gastric cells via down-regulation of Akt and then release of cytochrome c. Its anti-inflammatory effects allows for potential use in therapy for inflammatory allergic diseases.

Form
White Solid
Melting Point
146-148°C
Solubility
DMSO, Methaol
Pfizer Compound
References
Fan, X.M. et al.: Digestion, 2, 75 (2006); Kim, S. et al.: Life Sci., 81, 863 (2007); Kim, S. et al.: J. Pharmacol. Exp. Therap., 313, 27 (2005);
USBio References
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