(3α,4β,8α)-12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol 4,15-Diacetate 8-(3-Methylbutanoate); 12,13-Epoxytrichothec-9-ene-3α,4β,8α,15-tetrol 4,15-Diacetate 8-Isovalerate; 4β,15-Diacetoxy-8α-(3-methylbutyryloxy)-|12,13-epoxytrichothec-9-en-3α-ol; 8α-(3-Methylbutyryloxy)-4β,15-|diacetoxyscirp-9-en-3α-ol; Fusariotoxin T 2; Insariotoxin; Mycotoxin T 2; NSC 138780; T 2; T 2 mycotoxin; T-2 Lienomycin; Toxin T 2

T-2 toxin is a common trichothecene mycotoxin produced by Fusarium species, which can infect grain crops causing alimentary toxic aleukia in humans and animals. It triggers a ribotoxic response through its high binding affinity to peptidyl transferase, which is an integral part of the 60S ribosomal subunit, resulting in activation of JNK/p38 MAPKs, interferes with the metabolism of membrane phospholipids, and increases liver lipid peroxides.1 T-2 toxin is highly cytotoxic to macrophages, inducing apoptosis in primary porcine alveolar macrophage cells with an IC50 value of 19.47 nM. At 3 nM it decreases the production of inflammatory mediators (IL-1β, TNFα, and nitric oxide), TLR4, and TLR2/6 agonists.2