Tacedinaline CAS 112522-64-2

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021222 Tacedinaline CAS: 112522-64-2

Specifications

References

CAS Number

112522-64-2

Grade

Highly Purified

Molecular Formula

C15H15N3O2

Molecular Weight

269.3

EU Commodity Code

38220090

Shipping Temp

Storage Temp

4-(Acetylamino)-N-(2-aminophenyl)benzamide; Acetyldinaline; CI 994; Goe 5549; PD 123654;

Tacedinaline is a histone deacetylase (HDAC) inhibitor. Tacedinaline is an anti-cancer agent as HDAC inhibitors block angiogenesis, arrest cell growth, and lead to differentiation and apoptosis in tumor cells. Studies show Tacedinaline to be effective against acute myeloid leukemia in vitro and in vivo when used in combination with conventional anti-cancer agents.

References

Pontiki, E. et al.: Med, Res. Rev., 32, 1 (2012); Hubeek, I. et al.: Oncol. Rep., 19, 1517 (2008); Pauer, L.R. et al.: Cancer Invest., 22, 886 (2004); Nemunaitis, J.J. et al.: Cancer J., 9, 58 (2003);