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021288 Tauroursodeoxycholic Acid Sodium Salt (TUDC) CAS: 35807-85-3

Specifications
References
CAS Number
35807-85-3
Grade
Highly Purified
MDL Number
MFCD00065451
Molecular Formula
C26H44NNaO6S
Molecular Weight
521.69
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
2-[[(3α,5β,7β)-3,7-Dihydroxy-24-oxocholan-24-yl]amino]ethanesulfonic Acid Sodium Salt; 3α,7β-Dihydroxy-5β-cholan-24-oic Acid N-(2-Sulfoethyl)amide; Ursodeoxycholyltaurine; Sodium Tauroursodeoxycholate; TUDC

Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis. Tauroursodeoxycholate inhibits human cholangiocarcinoma growth via Ca2+-, PKC-, and MAPK-dependent pathways.

Synonyms
2-[[(3α,5β,7β)-3,7-Dihydroxy-24-oxocholan-24-yl]amino]ethanesulfonic Acid Sodium Salt; 3α,7β-Dihydroxy-5β-cholan-24-oic Acid N-(2-Sulfoethyl)amide; Ursodeoxycholyltaurine; Sodium Tauroursodeoxycholate; TUDC
Molecular Formula
C26H44NNaO6S
Molecular Weight
521.69
Appearance
White to off-white powder
Purity
≥98%
Melting Point
173-175°C
Solubility
DMSO (Slightly, Heated), Ethanol (Slightly, Sonicated), Methanol (Slightly)
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
1. Alvarez, E., et al.: J. Biol. Chem., 266, 15277 (1991). 2. Alvaro, D., et al.: J. Clin. Invest., 96, 665 (1995). 3. Alpini, G., et al.: Hepatology, 34, 868 (2001). 4. Higuchi, H., et al.: J. Biol. Chem., 278, 454 (2003).
USBio References
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