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021374 Terfenadine CAS: 50679-08-8

Specifications
References
CAS Number
50679-08-8
Grade
Highly Purified
Molecular Formula
C₃₂H₄₁NO₂
Molecular Weight
471.67
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol;|α-(p-tert-Butylphenyl)-4-(α-hydroxy-α-phenylbenzyl)-1-piperidinebutanol; Allerplus; Cyater; Histadin; MDL 9918; NSC 665802; (±)-Terfenadine

Nonsedating-type histamine H1-receptor antagonist. Antihistaminic.

Synonyms
α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol; α-(p-tert-Butylphenyl)-4-(α-hydroxy-α-phenylbenzyl)-1-piperidinebutanol; Allerplus; Cyater; Histadin; MDL 9918; NSC 665802; (±)-Terfenadine
CAS No
50679-08-8
Molecular Formula
C₃₂H₄₁NO₂
Molecular Weight
471.67
Purity
≥95%
Appearance
Supplied as a white Solid
Melting Point
148-150°C
Solubility
Chloroform (Slightly), Methanol (Slightly)
Method for Determining Identity
Proton NMR (CDCl3) Spectroscopic and Mass Spectrometric Analysis
TLC Conditions
SiO2; Dichloromethane: Methanol: Ammonium Hydroxide=9:1:0.1; Visualized with UV and AMCS; Single Spot, Rf=0.50
Elemental Analysis
Calculated: %C: 81.48, %H: 8.76, %N: 2.97
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at 4°C for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards:  All products should be handled by qualified personnel only, trained in laboratory procedures.
Purity
≥95%
Form
Supplied as a white solid
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Carr, A.A., et al.: Arzneim. Forsch., 32, 1157 (1982). 2. Badwan, A.A., et al.: Anal. Profiles Drug Subs., 19, 627 (1990). 3. Masheter, H.C., et al.: Clin. Rev. Allergy, 11, 5 (1993). 4. Jurima-Romet, M., et al.: Drug Metab. Dispos., 22, 849 (1994)
USBio References
No references available
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