N-Methyl-N-(3-methylphenyl)carbamothioic Acid O-2-Naphthalenyl Ester; Methyl(3-methylphenyl)carbamothioic Acid O-2-Naphthalenyl Ester; 2-Naphthyl N-Methyl-N-(3-tolyl)thiocarbamate; Aftate; Chinofungin; Dermoxin; Phytoderm; Pitrex; Sch 10144; Tolnaphthate; Tolsanil; Tonoftal; Tritin

Tolnaftate is used to study the mechanism of ergosterol (sterol) biosynthesis at the rate-limiting step of squalene epoxidase inhibition. Tolnaftate is clinically used to treat cutaneous infections such as athlete′s foot, jock itch, and ringworm. It also has been used as a comparator compound for antifungal efficiency studies. Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms. Tolnaftate inhibits biosynthesis of aflatoxin.