ZD 7288 CAS 133059-99-1

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022945 ZD 7288 CAS: 133059-99-1

Specifications

References

CAS Number

133059-99-1

Grade

Highly Purified

Molecular Formula

C₁₅H₂₁ClN₄

Molecular Weight

292.81

EU Commodity Code

38220090

Shipping Temp

Storage Temp

-20°C

N-Ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine Hydrochloride; N-Ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-|N-phenyl-4-pyrimidinamine Monohydrochloride; ICI-D 7288

ZD 7288 is a selective Ih channel inhibitor. ZD 7288 is an sino-atrial node function modulator; blocks the hyperpolarization activated cation current If. ZD 7288 blocks Ih in central neurons. ZD 7288 increases NMDA-evoked noradrenalin release in rat brain in vitro.

Synonyms

N-Ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine Hydrochloride; N-Ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)- N-phenyl-4-pyrimidinamine Monohydrochloride; ICI-D 7288

CAS No

133059-99-1

Molecular Formula

C₁₅H₂₁ClN₄

Molecular Weight

292.81

Appearance

Crystalline solid

Purity

≥98%

References

Vera, P., et al.: Brain Res. Bull., 29, 651 (1992), Su, X., et al.: J. Neurophysiol., 77, 1566 (1997), Ishii, T., et al.: J. Biol. Chem., 274, 12835 (1999), Masuda, N., et al.: Brain Res., 1096, 40 (2006)