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032130 Rabbit Anti-ASCL1, CT (D220) (Achaete-scute homolog 1, HASH1, ASH1)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_004307
Gene ID
429
Gene #
ASCL1
Shipping Temp
Blue Ice
Storage Temp
-20°C
Achaete-scute homolog 1, HASH1, ASH1

ACSL1, alternatively titled Hash1 or Mash1, is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. ACSL1 plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. The protein is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests it may also play a role in tumor formation.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-250
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
ASCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human ASCL1.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human
References
Sriuranpong, V., et al., Mol. Cell. Biol. 22(9):3129-3139 (2002).|Westerman, B.A., et al., Clin. Cancer Res. 8(4):1082-1086 (2002).|Chen, H., et al., Cell Growth Differ. 8(6):677-686 (1997).|Borges, M., et al., Nature 386(6627):852-855 (1997).|Renault, B., et al., Genomics 30(1):81-83 (1995).
USBio References
No references available
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