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041101 Rabbit Anti-Rnasen, ID (Drosha, Etohi2, Rn3, Rnasen, Ribonuclease 3, Protein Drosha, Ribonuclease III)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q5HZJ0
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_001123621.1
Gene ID
14000
Gene #
Rnasen
Shipping Temp
Blue Ice
Storage Temp
-20°C
Drosha, Etohi2, Rn3, Rnasen, Ribonuclease 3, Protein Drosha, Ribonuclease III

Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, RNASEN/DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies (By similarity).

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Mouse Rnasen antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 737-764 amino acids from the Central region of mouse Rnasen.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human
References
Chong, M.M., et al. Genes Dev. 24(17):1951-1960(2010)|Yang, J.S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(34):15163-15168(2010)|Michon, F., et al. Dev. Biol. 340(2):355-368(2010)|Wu, H., et al. PLoS ONE 4 (10), E7566 (2009) :|Shenoy, A., et al. PLoS ONE 4 (9), E6971 (2009) :
USBio References
No references available
Conjugates
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