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043080-FITC Rabbit Anti-TNFRSF6B, NT (TNFRSF6B, DCR3, TR6, Tumor necrosis factor receptor superfamily member 6B, Decoy receptor 3, Decoy receptor for Fas ligand, M68) (FITC)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
O95407
Conjugate
FITC
Isotype
IgG
Grade
Affinity Purified
Applications
FLISA IHC WB
Crossreactivity
Hu
Accession #
NP_116563.1; NP_003814.1
Gene ID
8771
Gene #
TNFRSF6B
Shipping Temp
Blue Ice
Storage Temp
-20°C
Notes
Preservative Free
TNFRSF6B, DCR3, TR6, Tumor necrosis factor receptor superfamily member 6B, Decoy receptor 3, Decoy receptor for Fas ligand, M68

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Overexpression of this gene has been noted in gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene.

Applications
Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry (Not Tested) and FLISA. Other applications have not been tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note: Applications are based on unconjugated antibody.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 22-48 in the N-terminal region of human TNFRSF6B, UniProt Accession #O95407; NP_116563.1; NP_003814.1
Form
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein isothiocyanate (FITC).
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human TNFRSF6B.
References
1. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) 2. Xiong, G., et al. Tumour Biol. 31(5):443-449(2010) 3. Sung, H.Y., et al. Int. J. Radiat. Biol. 86(9):780-790(2010) 4. Brunetti, G., et al. Ann. N. Y. Acad. Sci. 1192, 298-302 (2010) 5. Perdigones, N., et al. Arthritis Rheum. 62(3):705-710(2010)
USBio References
No references available
Conjugates
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